protein

ICAM-2/CD102 Protein, Human (HEK293, His)

HY-P7775

10 μg;50 μg

65;195 USD

ICAM-2/CD102 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

65;195 USD

ICAM-2/CD102 Protein, Human (HEK293, His) is a transmembrane glycoprotein of the immunoglobulin superfamily.

Human

ICAM-2 (CD102), like the structurally related ICAM-1 (CD54) and ICAM-3 (CD50) proteins is a known ligand for the ß2 family of leukocyte integrins. These include CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), and the dendritic cell-specific, ICAM-grabbing non-integrin (DC-SIGN) protein. ICAM-2 harbours two immunoglobulin domains which are homologues to the first and second immunoglobulin domain of ICAM-1 without any known splice variants. ICAM-2 is uniformly present on all subsets of B lymphocyte lineage cells in bone marrow cell suspensions. High level constitutive expression on vascular endothial cells and less responsiveness than ICAM-1 to inflammatory stimuli are also characteristics of ICAM-2. Recombinant ICAM-2 can co-stimulate T cells in vitro. Although ICAM-2 mediates neutrophil transmigration, ICAM-2 appears capable of mediating CD31/PECAM-1-independent leukocyte transmigration. ICAM-2 may also regulate angiogenesis via several mechanisms including survival, cell migration, and Rac activation [1] [2] .

rHuCD102, His; Intercellular Adhesion Molecule 2; ICAM-2; CD102; ICAM2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.