protein

MFG-E8 Protein, Mouse (HEK293, His)

HY-P77749

5 μg;10 μg;20 μg;50 μg;100 μg

40;63;100;220;375 USD

MFG-E8 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;20 μg;50 μg;100 μg

40;63;100;220;375 USD

The MFG-E8 protein plays a critical role in promoting the phagocytic clearance of apoptotic cells in various tissues.As a specific ligand, it interacts with alpha-v/beta-3 and alpha-v/beta-5 receptors and also binds independently to phosphatidylserine-rich cell surfaces.MFG-E8 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MFG-E8 protein, expressed by HEK293 , with N-His labeled tag.

Mouse

MFG-E8 (Milk Fat Globule-Epidermal Growth Factor 8) is a versatile protein that contributes significantly to the phagocytic removal of apoptotic cells in various tissues. Serving as a specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors, MFG-E8 facilitates the recognition and clearance of apoptotic cells by phagocytes. Additionally, it exhibits binding capabilities to phosphatidylserine-enriched cell surfaces independently of receptors. With its role as a zona pellucida-binding protein, MFG-E8 may contribute to gamete interactions (By similarity). Notably, MFG-E8 is crucial for maintaining intestinal epithelial homeostasis and promoting mucosal healing, highlighting its significance in gastrointestinal health. Furthermore, MFG-E8 plays a key role in promoting VEGF-dependent neovascularization, emphasizing its involvement in angiogenesis and tissue repair processes.

Lactadherin; MFGM; MFG-E8; SED1; MP47; BA46; EDIL1; HsT19888; Medin; MFG1; OAcGD3S; SPAG10

Greater than 95% as determined by Tris-Bis PAGE

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.