protein

TMEM219/IGFBP-3R Protein, Mouse (HEK293, Fc)

HY-P77697

20 μg;50 μg

168;370 USD

TMEM219/IGFBP-3R Protein, Mouse (HEK293, Fc)

proteins

HEK293

20 μg;50 μg

168;370 USD

The IGFBP-3R protein was identified as an IGFBP3-specific cell death receptor and becomes a potential mediator of caspase-8-dependent apoptosis upon ligand binding. This receptor actively interacts with IGFBP3, forming a key molecular connection that may initiate the apoptotic signaling cascade. TMEM219/IGFBP-3R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IGFBP-3R protein, expressed by HEK293 , with C-hFc labeled tag.

Mouse

IGFBP-3R, a cell death receptor specific for insulin-like growth factor binding protein 3 (IGFBP3), is implicated in mediating caspase-8-dependent apoptosis upon ligand binding. This receptor interacts directly with IGFBP3, suggesting a key role in transducing signals related to cell survival and death pathways. The binding of IGFBP3 to IGFBP-3R may trigger apoptotic cascades, potentially involving caspase-8. This interaction between IGFBP-3R and caspase-8 underscores the potential involvement of this receptor in regulating apoptotic processes.

IGFBP-3R; GFBP3R; LOC124446; TMEM219

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.