protein

IgE Protein, Mouse (HEK293, His-Avi)

HY-P77696

20 μg;50 μg

300;490 USD

IgE Protein, Mouse (HEK293, His-Avi)

proteins

HEK293

20 μg;50 μg

300;490 USD

IgE is an important component of the immunoglobulin chain that coordinates humoral immunity. As a receptor, membrane-bound IgE initiates clonal expansion and B cell differentiation. IgE Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived IgE protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IgE Protein, Mouse (HEK293, His-Avi) is 224 a.a., with molecular weight of 30-40 kDa.

Mouse

IgE, a crucial component of immunoglobulin heavy chains, plays a pivotal role in the intricate orchestration of humoral immunity. Serving as receptors during the recognition phase, membrane-bound immunoglobulins initiate clonal expansion and B lymphocyte differentiation into plasma cells upon antigen binding. In the effector phase, secreted immunoglobulins facilitate the elimination of bound antigens. The antigen-binding site, marked by remarkable affinity for specific antigens, results from the collaboration between the variable domains of one heavy chain and its associated light chain. Through V-(D)-J rearrangement and subsequent somatic hypermutations, the variable domains undergo affinity maturation, enhancing specificity for particular antigens. Structurally, each immunoglobulin consists of two identical heavy chains and two identical light chains, disulfide-linked. The N-terminal variable regions of the heavy and light chains constitute the antigen-binding sites, while the C-terminal constant regions of the heavy chains interact with immune receptors, driving effector functions. This dynamic interplay defines the versatile and precise role of IgE in orchestrating humoral immune responses.

Ig epsilon chain C region; IgE

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.