protein

Galectin-3/LGALS3 Protein, Mouse (HEK293, His)

HY-P77684

5 μg;10 μg;20 μg;50 μg;100 μg

70;110;178;300;510 USD

Galectin-3/LGALS3 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;20 μg;50 μg;100 μg

70;110;178;300;510 USD

Galectin-3/LGALS3 protein binds IgE and cooperates with integrins α-3 and β-1 to promote endothelial cell migration.It contributes to epithelial cell differentiation and acts as a splicing factor in the nucleus.Galectin-3/LGALS3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Galectin-3/LGALS3 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

Galectin-3 (LGALS3) functions as a galactose-specific lectin with the ability to bind IgE and, in collaboration with the alpha-3, beta-1 integrin, participates in the CSPG4-induced stimulation of endothelial cell migration. Alongside DMBT1, it is essential for the terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus, Galectin-3 acts as a pre-mRNA splicing factor. Outside the nucleus, it plays a crucial role in acute inflammatory responses, involving neutrophil activation and adhesion, monocyte macrophage chemoattraction, opsonization of apoptotic neutrophils, and mast cell activation. Furthermore, in coordination with TRIM16, Galectin-3 facilitates the recognition of membrane damage, mobilizing core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. The protein likely forms homo- or heterodimers and interacts with various partners, including DMBT1, CD6, ALCAM, ITGA3, ITGB1, CSPG4, LGALS3BP, LYPD3, ZFTRAF1, and UACA, with the interaction with TRIM16 mediating the autophagy of damaged endomembranes.

AGE-R3; CBP35; GAL3; Gal-3; galactin-3; GALBPCBP35; Galectin3; GALIG; L29; L31; Lectin L-29; LGALS2; LGALS3; Mac-2; MAC2GAL3

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, 300 mM L-Arginine, pH 7.4 or 50 mM HEPES, 150 mM NaCl, 5 mM EDTA, 2 mM TCEP, pH 7.4 or PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.