protein

EMAP-II Protein, Mouse (His)

HY-P77643

20 μg;50 μg;100 μg

157;347;590 USD

EMAP-II Protein, Mouse (His)

proteins

E. coli

20 μg;50 μg;100 μg

157;347;590 USD

EMAP-II is a noncatalytic component of the multisynthase complex (MSC) and plays a critical role in coordinating tRNA ligase function. It stimulates cytoplasmic arginyl-tRNA synthase and binds to tRNA. EMAP-II Protein, Mouse (His) is the recombinant mouse-derived EMAP-II protein, expressed by E. coli , with N-His labeled tag. The total length of EMAP-II Protein, Mouse (His) is 309 a.a., with molecular weight of 42-46 kDa.

Mouse

EMAP-II serves as a non-catalytic component within the multisynthase complex (MSC), playing a crucial role in orchestrating the functions of various tRNA ligases. It specifically stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase and binds to tRNA. Apart from its role in protein synthesis, EMAP-II exhibits inflammatory cytokine activity and negatively regulates TGF-beta signaling by stabilizing SMURF2 and inhibiting its SMAD7-mediated degradation. Additionally, EMAP-II contributes to glucose homeostasis through the induction of glucagon secretion, promotes dermal fibroblast proliferation and wound repair, and modulates endothelial cell responses by inducing migration at low concentrations and apoptosis at high concentrations. It forms homodimers and is part of the MSC, interacting with various tRNA ligases, SMURF2, HSP90B1/gp96, and PSMA7, showcasing its involvement in diverse cellular processes and regulatory networks.

EMAP-2; EMAP-II; AIMP1; HLD3; SCYE1; p43

Greater than 95% as determined by Tris-Bis PAGE

Supplied as a 0.22 μm filtered solution of 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.0.

Shipping with dry ice.