product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
CEACAM1 Protein, Mouse (HEK293, His)
catalog :
HY-P77630
quantity :
20 μg;50 μg
price :
150;280 USD
more info or order :
product information
Catalog Number :
HY-P77630
Product Name :
CEACAM1 Protein, Mouse (HEK293, His)
Product Type :
proteins
Host Species :
HEK293
Size :
20 μg;50 μg
List Price :
150;280 USD
Product Description :
The CEACAM1 protein is a cell adhesion molecule that mediates calcium-independent homologous cell adhesion. CEACAM1 negatively regulates neutrophil and platelet function, downregulates the CSF3R-STAT3 pathway, and modulates insulin clearance and lipogenesis. CEACAM1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CEACAM1 protein, expressed by HEK293 , with C-His labeled tag.
SpeciesSummary :
Mouse
Background :
CEACAM1 protein, functioning as a cell adhesion molecule, mediates homophilic cell adhesion in a calcium-independent manner. It plays a multifaceted role as a coinhibitory receptor in immune responses and insulin action, while also serving as an activator during angiogenesis. Through phosphorylation- and PTPN6-dependent mechanisms, CEACAM1 suppresses signal transduction of associated receptors, inhibiting T-cell cytotoxicity, proliferation, and cytokine production. Moreover, it regulates autoimmunity and anti-tumor immunity by interacting with HAVCR2. In NK cells, it inhibits KLRK1-mediated cytolysis and negatively regulates IL1B production in neutrophils. CEACAM1 down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R, and it also regulates insulin action by promoting INS clearance and controlling lipogenesis in the liver. Furthermore, it functions as an activator in angiogenesis, promoting blood vessel remodeling and arteriogenesis. CEACAM1 regulates vascular permeability, down-regulates cell growth in response to EGF, inhibits platelet aggregation, negatively regulates osteoclastogenesis, and contributes to the regulation of IgA production and secretion associated with microbiota control and resistance to enteropathogens.
ALTnames :
BGP; BGP1; BGPI; CEACAM1; CD66a
Purity :
Greater than 95% as determined by Tris-Bis PAGE.
Buffer :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Storage :
Room temperature in continental US; may vary elsewhere.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA