protein

IL-2R beta/CD122 Protein, Human (HEK293, His-Avi)

HY-P77594

20 μg;50 μg

280;495 USD

IL-2R beta/CD122 Protein, Human (HEK293, His-Avi)

proteins

HEK293

20 μg;50 μg

280;495 USD

IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K d : 1 nM approximately) [1] . IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells [2] . IL-2R beta/CD122 Protein, Human (HEK293, His-Avi) is a recombinant human extracellular region of IL-2R beta (A27-D239) with a C-Terminal His-Avi tag, which is produced in HEK293 cells.

Human

IL-2R beta (CD122) is a type I cytokine receptor, and belongs to Type 4 subfamily. IL-2R beta is also a key component of the IL-15 receptor. IL-2R beta is broadly expressed in spleen, blood, and lymph node, such as B and T lymphocytes [1] [3] . The sequence of amino acids in IL-2R beta differs in different species. Human IL-2R beta shares IL-2R beta cytoplasmic domain heterodimerizes with IL-2 and leads to the activation of signaling pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAP kinase, and the JAK-STAT pathways [4] . IL-2R beta binds IL-2 with intermediate affinity. IL-2R beta mediates IL-2 internalization and signal transduction, such as cell proliferation or differentiation [5] . IL-2R beta interacts with IL-2 and increases the proportion of CD4+ T lymphocytes [1] . IL-2R stimulates T cell proliferation and activating lymphokine-activated killer cells [2] . IL-2R beta mediates T cell immune responses, and also mediates endocytosis, as well as transducing the mitogenic signals of IL-2.

CD122; IL-15 R beta; IL-2 R beta; IL-2R subunit beta; IL2RB; P70-75; p75; RP5-1170K4.6

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.