protein

Calcitonin/CALCA Protein, Human (HEK293, Fc)

HY-P77586

5 μg;10 μg;20 μg;50 μg;100 μg;500 μg

45;70;110;210;340;950 USD

Calcitonin/CALCA Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;20 μg;50 μg;100 μg;500 μg

45;70;110;210;340;950 USD

Calcitonin/CALCA Protein (Human), a member of calcitonin-like protein family, is a peptide hormone secreted by parafollicular cells (C cells) of the thyroid (endostyle). Calcitonin/CALCA Protein (Human) reduces blood calcium Ca 2+ and inhibits the effects of parathyroid hormone ( PTH ), which is used an antagonist against PTH and Vitamin D3a . Calcitonin/CALCA Protein (Human) has been used widely for research of bone disorders such as osteoporosis, hypercalcemia, and Paget’s disease. Calcitonin/CALCA Protein, Human (HEK293, Fc) is a recombinant protein with a Fc label that consists of 141amino acids and is expressed in HEK293 [1] [2] [3] [4] [5] .

Human

Calcitonin, encoded by the CALCA gene, induces a rapid yet transient reduction in blood calcium and phosphate levels by facilitating the incorporation of these ions into bones. This hormone plays a crucial role in calcium homeostasis, functioning as a counter-regulatory mechanism to maintain balanced mineral levels in the bloodstream. Additionally, katacalcin, a peptide derived from the CALCA gene, is identified as a potent plasma calcium-lowering factor. The ability of calcitonin to modulate bone resorption and regulate circulating mineral concentrations underscores its significance in skeletal health and systemic mineral balance. Further exploration of the molecular pathways involved in these actions may contribute to a deeper understanding of calcitonin's role and potential therapeutic applications in conditions related to abnormal calcium metabolism [1] . Calcitonin/CALCA Protein (Human) lowers blood Ca 2+ levels by inhibiting osteoclast activity in bones and Inhibiting renal tubular cell reabsorption of Ca 2+ and phosphate leading to marked hypocalcemia [3] . Calcitonin/CALCA Protein (Human) protects against calcium loss from the skeleton by the direct inhibition of bone resorption and the indirect effect through the inhibition of the release of prolactin from the pituitary gland during periods of calcium mobilization in skeleton-preserving actions [6,7] . Calcitonin/CALCA Protein (Human) lowers blood calcium and phosphorus mainly through its inhibition of osteoclasts and prevents postprandial hypercalcemia resulting from absorption of Ca 2+ [8] .

Calcitonin; CCP; PDN-21; CALCA; CALC1; CGRP; CGRP-I; CGRP1; CT; KC; PCT; Procalcitonin; Calcitonin 1; Katacalcin

Greater than 95% as determined by Tris-Bis PAGE or SDS-PAGE

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.