protein

Cathepsin Z/CTSZ Protein, Human (HEK293, His, solution)

HY-P7758

10 μg;50 μg

165;450 USD

Cathepsin Z/CTSZ Protein, Human (HEK293, His, solution)

proteins

HEK293

10 μg;50 μg

165;450 USD

Cathepsin Z/CTSZ Protein, Human (HEK293, His, solution) is a lysosomal cysteine protease, found predominantly in cells of monocyte/macrophage lineage.

Human

Cathepsin X acts as a monocarboxypepidase and has a strict positional and narrower substrate specificity relative to the other human cathepsins. The via activation of β2 integrin receptor Mac-1 (CD11b/CD18) active cathepsin X enhances adhesion of monocytes/macrophages to fibrinogen and regulates the phagocytosis. By activation of Mac-1 receptor cathepsin X may regulate also the maturation of dendritic cells, a process, which is crucial in the initiation of adaptive immunity. Cathepsin X activates also the other β2 integrin receptor, LFA-1 (CD11a/CD18) which is involved in the proliferation of T lymphocytes. The cleavage of C-terminal amino acids of alpha and gamma enolase by cathepsin X abolishes their neurotrophic activity affecting neuronal cell survival and neuritogenesis. Cathepsin X is a cysteine carboxypeptidase, localized predominantly in immune cells, regulating their proliferation, maturation, migration and adhesion [1] [2] .

rHuCathepsin X, His; Cathepsin Z; Cathepsin P; Cathepsin X; CTSZ

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filter solution of 20 mM HAc-NaAc, 150 mM NaCl, pH 4.0 or 4 mM HCl.

Shipping with dry ice.