protein

Annexin A2/ANXA2 Protein, Mouse (His)

HY-P77561

5 μg;10 μg;20 μg;50 μg;100 μg;500 μg

36;62;105;230;390;880 USD

Annexin A2/ANXA2 Protein, Mouse (His)

proteins

E. coli

5 μg;10 μg;20 μg;50 μg;100 μg;500 μg

36;62;105;230;390;880 USD

Annexin A2/ANXA2 protein is a calcium-regulated membrane-binding protein that binds two calcium ions. Annexin A2/ANXA2 Protein, Mouse (His) is the recombinant mouse-derived Annexin A2/ANXA2 protein, expressed by E. coli , with N-His labeled tag. The total length of Annexin A2/ANXA2 Protein, Mouse (His) is 338 a.a., with molecular weight of ~39.6 kDa.

Mouse

Annexin A2 (ANXA2) is a calcium-regulated membrane-binding protein with heightened calcium affinity in the presence of anionic phospholipids. Known for its potential involvement in the heat-stress response, ANXA2 operates as a heterotetramer, comprising two light chains of S100A10/p11 and two heavy chains of ANXA2/p36. It inhibits PCSK9-enhanced LDLR degradation, potentially through translational mechanisms, while also competing with LDLR for PCSK9 binding. ANXA2 interacts with various proteins, including ATP1B1, DYSF, COCH, and CEACAM1, with the latter interaction being regulated by CEACAM1 phosphorylation. Moreover, ANXA2 interacts with PCSK9, forming a complex that hinders LDLR degradation. Additionally, it associates with APPL2 and APPL1, facilitating the targeting of APPL2 to endosomes in parallel with RAB5A. The intricate network of ANXA2 interactions underscores its versatile role in cellular processes and regulatory pathways.

Chromobindin-8; Lipocortin II; PAP-IV; ANX2; ANX2L4; CAL1H; LPC2D; ANXA2; Annexin A2; Annexin II; LIP2PAP-IV; LPC2D; LPC2DP36; p36

Greater than 95% as determined by Tris-Bis PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, 4 mM DTT, pH 7.4 or 20 mM PBS, 150 mM NaCl, pH 8.0.

Room temperature in continental US; may vary elsewhere.