protein

Cathepsin L1 Protein, Human (HEK293, His, solution)

HY-P7754

10 μg;50 μg

140;420 USD

Cathepsin L1 Protein, Human (HEK293, His, solution)

proteins

HEK293

10 μg;50 μg

140;420 USD

Cathepsin L1 Protein, Human (HEK293, His, solution) is a major cysteine protease that plays a major role in intracellular protein catabolism.

Human

Cathepsin L1, a major cysteine protease secreted by the parasite plays a pivotal role in various aspects of its pathogenicity. For example, Cathepsin L1 takes part in nutrient acquisition by catabolizing host proteins to absorbable peptides, facilitates the migration of the parasite through the host intestine and liver by cleaving interstitial matrix proteins such as fibronectin, laminin, and native collagen, and is implicated in the inactivation of host immune defenses by cleaving immunoglobulins. Cathepsin L1 suppresses Th1 immune responses in infected laboratory animals making them susceptible to concurrent bacterial infections [1] .

rHuCathepsin L1, His; Cathepsin L1; Major Excreted Protein; MEP; CTSL1; CTSL

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filter solution of 20 mM HAc-NaAc, 150 mM NaCl, pH 4.5.

Shipping with dry ice.