protein

WWP2 Protein, Human (sf9, His-GST)

HY-P77507

5 μg;20 μg;50 μg

60;120;265 USD

WWP2 Protein, Human (sf9, His-GST)

proteins

Sf9 insect cells

5 μg;20 μg;50 μg

60;120;265 USD

The WWP2 protein is an E3 ubiquitin protein ligase that coordinates multiple ubiquitination events, including “Lys-63”-linked polyubiquitination of POU5F1, targeting it for proteasomal degradation in embryonic stem cells (ESCs). WWP2 also ubiquitinates EGR2, inhibits activation-induced cell death in T cells, and targets SLC11A2, which is enhanced by NDFIP1 and NDFIP2. WWP2 Protein, Human (sf9, His-GST) is the recombinant human-derived WWP2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

Human

WWP2 Protein, functioning as an E3 ubiquitin-protein ligase, facilitates the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to its targeted substrates. Notably, WWP2 engages in the polyubiquitination of POU5F1 through 'Lys-63'-linked conjugation, leading to the proteasomal degradation of POU5F1. In embryonic stem cells (ESCs), this ubiquitination is proposed to play a regulatory role in controlling the protein levels of POU5F1. Additionally, WWP2 ubiquitinates EGR2, promoting its proteasomal degradation, and in T-cells, this ubiquitination is implicated in inhibiting activation-induced cell death. Moreover, WWP2 targets SLC11A2 for ubiquitination, a process enhanced in the presence of NDFIP1 and NDFIP2. Furthermore, WWP2 ubiquitinates RPB1, leading to its proteasomal degradation. These diverse ubiquitination events underscore the regulatory versatility of WWP2 in modulating the stability and abundance of key proteins involved in various cellular processes.

NEDD4-like E3 ubiquitin-protein ligase WWP2; Atrophin-1-interacting protein 2; AIP2; WWP2

Greater than 90% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 8.0, 10% Glycerol.

Shipping with dry ice