protein

TM4SF2/TSPAN7 Protein, Human (HEK293, His)

HY-P77497

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

40;70;200;340;950;1615 USD

TM4SF2/TSPAN7 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

40;70;200;340;950;1615 USD

TM4SF2/TSPAN7 Protein is a member of the tetraspanin family. It mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN7 promotes apoptosis and inhibits tumor growth and cell cycle progression in BCa via the regulation of multiple key components of the PTEN/PI3K/AKT pathway. During cell differentiation, TSPAN7 emerges as a master regulator of morphological changes through cytoskeletal remodeling. TM4SF2/TSPAN7 Protein, Human (HEK293, His) is the recombinant human-derived TM4SF2/TSPAN7 protein, expressed by HEK293 , with C-His labeled tag. The total length of TM4SF2/TSPAN7 Protein, Human (HEK293, His) is 101 a.a., with molecular weight of 24-30 kDa.

Human

Tetraspanin-7 (TSPAN7) is a member of the tetraspanin family. It mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Notably, this encoded cell surface glycoprotein has been demonstrated to exert a vital role in the control of neurite outgrowth. Overexpression of TSPAN7 activates Bax, cleaves caspase-3 and PTEN, and inhibits BCa cell growth through the PTEN/PI3K/AKT pathway. Low expression of TSPAN7 is associated with response to oxidative stress, regulation of MAPK, cell population of proliferation, response to tumor necrosis factor, regulation of cell migration, negative regulation of programmed cell death and angiogenesis. In addition, TSPAN7 plays an important role in the cytoskeletal organization required for the bone-resorbing function of osteoclasts by regulating signaling to Src, Pyk2, and microtubules [1] [2] .

Tetraspanin-7; Tspan-7; CD231; Mxs1; Tm4sf2

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.