protein

L-selectin/CD62L Protein, Cynomolgus (HEK293, His)

HY-P77483

5 μg;10 μg;50 μg;100 μg

35;50;140;240 USD

L-selectin/CD62L Protein, Cynomolgus (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

35;50;140;240 USD

L-selectin/CD62L is a calcium-dependent lectin that aids cell adhesion by binding to neighboring glycoproteins. It mediates lymphocyte adhesion to endothelial cells in peripheral lymph nodes, causing leukocytes to tether and roll. L-selectin/CD62L Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived L-selectin/CD62L protein, expressed by HEK293 , with C-His labeled tag. The total length of L-selectin/CD62L Protein, Cynomolgus (HEK293, His) is 304 a.a., with molecular weight of 52-63 kDa.

Cynomolgus

L-selectin, a calcium-dependent lectin, facilitates cell adhesion by binding to glycoproteins on neighboring cells. It plays a significant role in the adherence of lymphocytes to endothelial cells in high endothelial venules of peripheral lymph nodes and promotes the initial tethering and rolling of leukocytes in endothelial tissues. The interaction between L-selectin and SELPLG/PSGL1 and PODXL2 is crucial for the recruitment and rolling of leukocytes, which relies on the sialyl Lewis X glycan modification of SELPLG and PODXL2, as well as the tyrosine sulfation modifications of SELPLG. Notably, sulfation on 'Tyr-51' of SELPLG is particularly important for the binding of L-selectin.

L-selectin; Sell; CD62 antigen-like family member L; LECAM1; CD62L; LAM-1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.