protein

Nectin-1 Protein, Mouse (HEK293, His)

HY-P77469

5 μg;10 μg;50 μg;100 μg

40;70;200;340 USD

Nectin-1 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

40;70;200;340 USD

Nectin-1 is critical in cell adhesion and synaptogenesis, promotes neurite outgrowth, and serves as a receptor for alphaherpesviruses, including HSV-1, HSV-2, and pseudorabies virus. It promotes viral entry and is involved in homodimerization, trans-heterodimerization with NECTIN3, and interactions with FGFR, AFDN, and HSV glycoprotein D. Nectin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Nectin-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Nectin-1 Protein, Mouse (HEK293, His) is 324 a.a., with molecular weight of ~37.6 KDa.

Mouse

Nectin-1, a pivotal player in cell adhesion and synaptogenesis, exhibits neurite outgrowth-promoting activity, underscoring its importance in neurodevelopmental processes. Functioning as a receptor for alphaherpesviruses, including HSV-1, HSV-2, and pseudorabies virus, Nectin-1 facilitates viral entry into cells. The protein engages in both cis- and trans-homodimerization and can also form trans-heterodimers with NECTIN3, initiating the formation of puncta adherentia junctions crucial for axon-dendrite interactions. Additionally, its interaction with FGFR1, FGFR2, and FGFR3, as well as AFDN, establishes connections with the actin cytoskeleton, contributing to its diverse cellular roles. Notably, Nectin-1 interacts with HSV glycoprotein D (gD), highlighting its involvement in viral infection processes.

Poliovirus Receptor-Related Protein 1; Herpes Virus Entry Mediator C; Herpesvirus Entry Mediator C; HveC; Herpesvirus Ig-Like Receptor; HIgR; Nectin-1; CD111; PVRL1; HVEC; PRR1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.