protein

Caspase-14/CASP14 Protein, Human (His)

HY-P7743

10 μg;50 μg

165;496 USD

Caspase-14/CASP14 Protein, Human (His)

proteins

E. coli

10 μg;50 μg

165;496 USD

Caspase-14 Protein, Human (His) is an approximately 31.0 kDa caspase-14 protein with a His-flag. Caspase-14 is a seemingly non-apoptotic caspase involved in keratinocyte differentiation and cornification [3] .

Human

Caspase 14 is a member of the caspase family. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin [1] . Caspase-14 is a protease that is mainly expressed in suprabasal epidermal layers and activated during keratinocyte cornification [2] . In contrast to many other caspase family members, murine caspase-14 is not cleaved by granzyme B, caspase-1, caspase-2, caspase-3, caspase-6, caspase-7 or caspase-11, but is weakly processed into p18 and p11 subunits by murine caspase-8 [2] . Caspase-14 is a seemingly non-apoptotic caspase involved in keratinocyte differentiation and cornification. Caspase-14 possesses a conserved role in barrier formation through involvement in terminal differentiation and fusion of the cytotrophoblast [3] .

rHuCaspase-14, His; Caspase-14; CASP-14; CASP14

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.