protein

IL-1RAcP/IL-1 R3 Protein, Human (HEK293, Fc)

HY-P77413

5 μg;10 μg;50 μg;100 μg

49;84;235;400 USD

IL-1RAcP/IL-1 R3 Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

49;84;235;400 USD

IL-1RAcP is a co-receptor for IL1RL2, IL1R1 and IL1RL1 in the IL-36, IL-1 and IL-33 signaling system, respectively. IL-1RAcP is an essential component of the IL-1 receptor and plays an essential role in the inflammatory process [1] [2] . IL-1RAcP/IL-1 R3 Protein, Human (HEK293, Fc) is a recombinant human IL-1RAcP protein with an hFc tag at the C-terminus and is expressed in HEK293 cells. It consists of 359 amino acids (M1-E359).

Human

Interleukin-1 receptor accessory protein (IL-1RAcP), also known as IL-1 R3, belongs to the immunoglobulin (Ig) superfamily. IL-1RAcP can be detected in liver, skin, placenta, thymus and lung. The human IL-1RAcP protein shares 89.12% a.a sequence identity with mouse and 88.95% identity with rat. IL-1RAcP contains three Ig-like domains and a cytoplasmic domain named Toll/IL-1 receptor (TIR) (position: 403-546 a.a), which has been implicated in signal transduction. IL-1RAcP also contains a single transmembrane region. IL-1RAcP is a co-receptor for IL1RL2, IL1R1 and IL1RL1 in the IL-36, IL-1 and IL-33 signaling system, respectively. IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, links events at the plasma membrane level to downstream signaling pathways, mediates interleukin-1-dependent transcription factor activation and gene expression. IL-1RAcP plays an essential role in the inflammatory process and can be used for the research of obesity, diabetics, endometriosis, atherosclerosis, and so on [1] [2] [3] .

Interleukin-1 Receptor Accessory Protein; IL-1RAcP; Interleukin-1 Receptor 3; IL-1R3; IL1RAP; C3orf13

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.