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company name :
MedChem Express LLC
product type :
protein
product name :
IL-1R2 Protein, Cynomolgus (HEK293, Fc)
catalog :
HY-P77410
quantity :
2 μg;10 μg;50 μg;100 μg;500 μg
price :
35;65;180;290;870 USD
more info or order :
product information
Catalog Number :
HY-P77410
Product Name :
IL-1R2 Protein, Cynomolgus (HEK293, Fc)
Product Type :
proteins
Host Species :
HEK293
Size :
2 μg;10 μg;50 μg;100 μg;500 μg
List Price :
35;65;180;290;870 USD
Product Description :
IL-1R2 is a competitive endogenous inhibitor of IL-1 signaling. IL-1R2 serves as a decoy receptor and competes with IL-1R1 for IL-1, it can also form a complex with IL-1RAP once it binds IL-1. IL-1R2 is implicated in various IL-1-mediated inflammatory diseases [1] . IL-1R2 Protein, Cynomolgus (HEK293, Fc) is a recombinant cynomolgus IL-1R2 protein with an hFc tag at the C-terminus and is expressed in HEK293 cells. It consists of 343 amino acids (M1-E343).
SpeciesSummary :
Cynomolgus
Background :
IL-1R2 is the non-signaling type 2 interleukin-1 receptor and is natively found on neutrophils, B-cells, monocytes and macrophages. IL-1R2 can be cleaved into two forms: membrane form and soluble form.
The sequence of amino acids in IL-1R2 from cynomolgus shows low similarity (about 60%) with both mouse and rat IL-1R2, but shows very high similarity with human IL-1R2 (95.43%).
IL-1R2 contains truncated cytoplasmic domain and lacks Toll-IL-1 receptor (TIR) region, making it incapable of transmembrane signaling. IL-1R2 serves as an endogenous inhibitor of IL-1 signaling. Functional IL-1 signaling requires IL-1R1 and IL-1-dependent recruitment of IL-1RAP. IL-1R2 serves as a decoy receptor and can compete with IL-1R1 for IL-1. IL-1R2 can also form a complex with IL-1RAP once it binds IL-1, preventing IL-1RAP from heterodimerizing with IL-1R1. Through these 2 ways, IL-1R2 blocks IL-1 signaling. Additionally, soluble IL-1R2 recruits soluble IL-1RAP with high affinity without impacting affinity for IL-1RA.
IL-1R2 inhibits IL-1 signaling and has been implicated in various IL-1-mediated inflammatory diseases like arthritis, diabetes, gout and so on [1] [2] [3] .
ALTnames :
Interleukin-1 receptor type 2;
IL-1R-2; CDw121b; IL-1R-beta; CD121b; mIL-1R2; sIL-1R2
Purity :
Greater than 95% as determined by reducing SDS-PAGE
Buffer :
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Storage :
Room temperature in continental US; may vary elsewhere.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA