protein

IL-11R alpha Protein, Rat (HEK293, His)

HY-P77400

2 μg;10 μg;50 μg

35;55;150 USD

IL-11R alpha Protein, Rat (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg

35;55;150 USD

IL-11R alpha (IL-11RA) is the IL-11 receptor subunit α and also acts as an agonist of IL-11. IL-11R alpha binds to IL6ST/gp130 on cell surfaces and induces signal transduction [1] . IL-11R alpha activates Jak family of tyrosine kinases, JAK1, JAK2, and TYK2 [3] . IL-11R alpha induces proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells [4] . IL-11R alpha plays an important role in the progression and the differentiation of human gastric carcinomas [5] . IL-11R alpha Protein, Rat (HEK293, His) is a recombinant protein with a His label that consists of 366 amino acids (M1-Q366) and is produced by HEK293 cells.

Rat

IL-11RA is highly expressed on stromal cells, including fibroblasts, smooth muscle cells, adipocytes, and hepatic/pancreatic stellate cells or pericytes, and also on epithelial/polarized cells, such as hepatocytes, alveolar epithelial cells, and kidney tubular epithelial cells [1] . The amino acid sequence of human IL-11R alpha protein has low homology between mouse and rat IL-11R alpha protein. IL-11R alpha is the receptor of IL-11, and signaling mechanism triggered by IL-11 is mediated through IL-11R alpha. IL-11R alpha can bind IL-11 and then the comples attracts gp130 leading to signal transduction. Besides, IL11RA has been demonstrated to activate IL-11-mediated gp130 signaling but not the naturally occurring form of the soluble IL-11 receptor. Binding of IL-11 to IL11RA triggers heterodimerization, tyrosine phosphorylation, and activation of gp130. The activated IL11RA–gp130 receptor complex further activates Jak family of tyrosine kinases, JAK1, JAK2, and TYK2 [3] . IL-11R alpha also acts as IL-11 agonist in vitro [3] . IL-11R alpha induces proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells [4] [5] .

IL-11 R alpha; IL11R alpha; IL11RA; IL-11Ra; Il11ra2; NR1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.