product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
IL-11R alpha Protein, Canine (HEK293, Fc)
catalog :
HY-P77398
quantity :
50 μg
price :
500 USD
more info or order :
product information
Catalog Number :
HY-P77398
Product Name :
IL-11R alpha Protein, Canine (HEK293, Fc)
Product Type :
proteins
Host Species :
HEK293
Size :
50 μg
List Price :
500 USD
Product Description :
IL-11R alpha (IL-11RA) is the IL-11 receptor subunit α and also acts as an agonist of IL-11. IL-11R alpha binds to IL6ST/gp130 on cell surfaces and induces signal transduction [1] . IL-11R alpha activates Jak family of tyrosine kinases, JAK1, JAK2, and TYK2 [3] . IL-11R alpha induces proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells [4] . IL-11R alpha plays an important role in the progression and the differentiation of human gastric carcinomas [5] . IL-11R alpha Protein, Canine (HEK293, Fc) is a recombinant protein with a Fc label produced by HEK293 cells.
SpeciesSummary :
Canine
Background :
IL-11RA is highly expressed on stromal cells, including fibroblasts, smooth muscle cells, adipocytes, and hepatic/pancreatic stellate cells or pericytes, and also on epithelial/polarized cells, such as hepatocytes, alveolar epithelial cells, and kidney tubular epithelial cells [1] .
The amino acid sequence of human IL-11R alpha protein has low homology between mouse and rat IL-11R alpha protein.
IL-11R alpha is the receptor of IL-11, and signaling mechanism triggered by IL-11 is mediated through IL-11R alpha. IL-11R alpha can bind IL-11 and then the comples attracts gp130 leading to signal transduction. Besides, IL11RA has been demonstrated to activate IL-11-mediated gp130 signaling but not the naturally occurring form of the soluble IL-11 receptor. Binding of IL-11 to IL11RA triggers heterodimerization, tyrosine phosphorylation, and activation of gp130. The activated IL11RA–gp130 receptor complex further activates Jak family of tyrosine kinases, JAK1, JAK2, and TYK2 [3] .
IL-11R alpha also acts as IL-11 agonist in vitro [3] . IL-11R alpha induces proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells [4] [5] .
ALTnames :
IL-11 R alpha; IL11R alpha; IL11RA; IL-11Ra; Il11ra2; NR1
Purity :
Greater than 80% as determined by reducing SDS-PAGE
Buffer :
Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
Storage :
Shipping with dry ice
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA