protein

HEPACAM2 Protein, Rat (HEK293, His)

HY-P77379

5 μg;10 μg;50 μg;100 μg

56;95;265;450 USD

HEPACAM2 Protein, Rat (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

56;95;265;450 USD

The HEPACAM2 gene encodes a protein associated with an immunoglobulin superfamily that plays a role in mitosis. Knocking down this gene can lead to prophase cell arrest, abnormal nuclear morphology and apoptosis . HEPACAM2 can be used as a biomarker for the prognosis of colorectal adenocarcinoma. HEPACAM2 Protein, Rat (HEK293, His) is the recombinant rat-derived HEPACAM2 protein, expressed by HEK293 , with C-His labeled tag. The total length of HEPACAM2 Protein, Rat (HEK293, His) is 318 a.a., with molecular weight of approximately 55-75 kDa.

Rat

HepaCAM, an N-linked glycoprotein encoding a member of the immunoglobulin superfamily, is a tumor suppressor gene that mediates multiple cellular biological functions. HepaCAM may be a novel therapeutic target for inhibiting bladder cancer proliferation through the AKT/FoxO pathway. The HEPACAM2 gene encodes a protein associated with an immunoglobulin superfamily that plays a role in mitosis. Knocking down this gene can lead to prophase cell arrest, abnormal nuclear morphology and apoptosis . The polymerization (ADP-ribosylation) of the encoding protein promotes its translocation to the centrosome, which may stimulate centrosome maturation. Deletion of chromosomes containing this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. HEPACAM2 can be used as a biomarker for the prognosis of colorectal adenocarcinoma [1] [2] [3] .

HEPACAM family member 2; Mitotic kinetics regulator; MIKI

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.