protein

GFRA1/GDNFR-alpha-1 Protein, Canine (HEK293, His)

HY-P77371

2 μg;10 μg;50 μg

35;85;215 USD

GFRA1/GDNFR-alpha-1 Protein, Canine (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg

35;85;215 USD

GFRA1 is a co-receptor that recognizes the GDNF ligand family and is involved in the regulation of proliferation, differentiation and migration of neuronal cells. GFRA1 promotes autophagy through the SRC-AMP-activated protein kinase ( AMPK ) signaling pathway, thereby contributing to the development of cisplatin-induced chemotherapy resistance to osteosarcoma. GFRA1/GDNFR-alpha-1 Protein, Canine (HEK293, His) is the recombinant canine-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-His labeled tag.

Canine

Glycosylphosphatidylinositol-linked GDNF (glial cell-derived neurotrophic factor) receptor alpha (GFRA) is a co-receptor that recognizes the GDNF ligand family and plays a critical role in the development and maintenance of the nervous system. GFRA1 is involved in the regulation of proliferation, differentiation and migration of neuron cells. GFRA1 has also been implicated in the progression and metastasis of cancer cells. GFRA1 promotes autophagy through the SRC-AMP-activated protein kinase ( AMPK ) signaling pathway, thereby contributing to the development of cisplatin-induced chemotherapy resistance to osteosarcoma [1] [2] [3] .

GDNF family receptor alpha-1; GFR-alpha-1; GDNFRA; TRNR1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.