protein

EphB6 Protein, Cynomolgus (HEK293, Fc)

HY-P77361

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

30;70;175;280;780;1250 USD

EphB6 Protein, Cynomolgus (HEK293, Fc)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

30;70;175;280;780;1250 USD

EphB6 is a member of the receptor tyrosine kinase family expressed primarily in thymic cells and T cell subpopulations. EphB6, when stimulated by ephrin-B2, inhibited JNK activation, and decreased T-cell receptor-induced IL-2 secretion and CD25 expression. EphB6 promotes colorectal epithelial cell transformation and may serve as a novel biomarker and therapeutic target for colorectal cancer. EphB6 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived EphB6 protein, expressed by HEK293 , with C-hFc labeled tag.

Cynomolgus

EphB6 is a member of the Eph receptor tyrosine kinases family and is mainly expressed in thymocytes and T cell subsets, suggesting that EphB6 may be involved in the regulation of T lymphocyte differentiation and function. EphB6 is a kinase-deficient receptor that specifically interacts with ephrin-B family members as a binding partner for ephrin-B1 and ephrin-B2. This receptor, which regulates cell adhesion and migration, showed subtle effects, both positive and negative, in response to ephrin-B2 stimulation. EphB6, when stimulated by ephrin-B2, inhibited JNK activation, and decreased T-cell receptor-induced IL-2 secretion and CD25 expression. EphB6 promotes colorectal epithelial cell transformation and may serve as a novel biomarker and therapeutic target for colorectal cancer [1] [2] [3] .

Ephrin type-B receptor 6; HEP; Tyrosine-protein kinase-defective receptor EPH-6; EPHB6

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.