protein

ENPP-7 Protein, Human (HEK293, His)

HY-P77358

5 μg;10 μg;50 μg;100 μg

60;105;290;495 USD

ENPP-7 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

60;105;290;495 USD

The ENPP-7 protein is a choline-specific phosphodiesterase that plays multiple roles in sphingomyelin digestion, ceramide formation, and fatty acid absorption in the gastrointestinal tract. It hydrolyzes sphingomyelin, releases ceramide and phosphocholine, and promotes the breakdown of sphingomyelin. ENPP-7 Protein, Human (HEK293, His) is the recombinant human-derived ENPP-7 protein, expressed by HEK293 , with C-His labeled tag. The total length of ENPP-7 Protein, Human (HEK293, His) is 418 a.a., with molecular weight of ~50-70 kDa.

Human

ENPP-7 protein operates as a choline-specific phosphodiesterase with multifaceted roles in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption within the gastrointestinal tract. Notably, it hydrolyzes sphingomyelin, releasing ceramide and phosphocholine, thereby participating in the intricate processes of sphingomyelin breakdown and subsequent ceramide production. Additionally, ENPP-7 displays phospholipase C activity, cleaving phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF), leading to their inactivation. Despite lacking nucleotide pyrophosphatase activity, ENPP-7 may play a role in promoting cholesterol absorption by influencing the levels of sphingomyelin derived from both dietary and endogenous sources within the intestinal lumen. These diverse enzymatic activities highlight the multifunctional role of ENPP-7 in lipid metabolism and absorption processes, underscoring its significance in gastrointestinal physiology.

Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; NPP-7; Alk-Smase

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.