protein

Carboxypeptidase B2/CPB2 Protein, Human (HEK293, His)

HY-P7735

10 μg;50 μg

115;345 USD

Carboxypeptidase B2/CPB2 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

115;345 USD

Carboxypeptidase B2 Protein, Human (HEK293, His) is an approximately 47.0 kDa human carboxypeptidase B2 with a His-flag. Carboxypeptidase B2 is a enzyme belonging to the peptidase M14 family and hydrolyze C-terminal peptide bonds [1] .

Human

Carboxypeptidase B2 is a secreted glycoprotein member of the peptidase M14 family of enzymes. It is expressed by hepatocytes and platelets, with MW differences attributable to glycosylation. CPB2 can be cleaved by thrombin and plasmin, generating a relatively insoluble nonglycosylated enzymatically active fragment (TAFIa). Active CPB2 removes C-terminal Lys residues from fibrin, thereby interrupting plasmin generation and promoting fibrin polymerization. Human CPB2 proprecursor is 401 amino acids (aa) in length. It contains a prosequence (aa 23-114) and an active fragment (aa 115-423) that acts on C-terminal Lys or Arg residues [1] [2] .

rHuCarboxypeptidase B2, His; Carboxypeptidase B2; Carboxypeptidase U; Plasma Carboxypeptidase B; Thrombin-Activable Fibrinolysis Inhibitor; CPB2

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filter solution of 20 mM Tris-HCl, 150 mM NaCl, 1 mM ZnCl 2 , 10% Glycerol, pH 7.5.

Shipping with dry ice.