protein

Can f 4 Protein, Canine (HEK293, His)

HY-P77310

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

39;66;185;314;880;1408 USD

Can f 4 Protein, Canine (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

39;66;185;314;880;1408 USD

Can f 4 Protein, Canine (HEK293, His), an IgE-binding dog dander protein, is an important respiratory allergen. Can f 4 Protein is a dog allergen of the lipocalin family [1] . Can f 4 Protein, Canine (HEK293, His) is the recombinant canine-derived Can f 4 protein, expressed by HEK293 , with C-His, C-6*His labeled tag.

Canine

Dog dander is a common cause of respiratory allergy, with symptoms including rhinitis, conjunctivitis and bronchial asthma. Extracts of dog hair and dander contain a complexity of allergenic and non-allergenic proteins. To date, the IgE reactivity of 4 dog allergens of the lipocalin protein family, Canf1, Canf2, Canf4, and Canf6, as well as the dog serum albumin Canf3 and the dog prostatic kallikrein Canf5, has been characterized in detail. The size and the amino acid composition of the ligand-binding pocket indicate that Canf4 is capable of binding only relatively small hydrophobic molecules which are different from those that Canf2 is able to bind. The crystal structure of Canf4 contained both monomeric and dimeric forms of the allergen, suggesting that Canf4 is able to form transient (weak) dimers. The dimeric structure of Canf4 is formed when the ends of four β-strands are packed against the same strands from the second monomer [1] [2] .

Allergen Can f 4

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM NaCl, pH 8.0.

Room temperature in continental US; may vary elsewhere.