protein

ADAM8 Protein, Rhesus Macaque (HEK293, His)

HY-P77293

5 μg;10 μg;50 μg

50;85;240 USD

ADAM8 Protein, Rhesus Macaque (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

50;85;240 USD

ADAM8 is a transmembrane glycoprotein containing metalloproteinase and disintegrin domains, belonging to the ADAMs family. It has proteolytic, cell adhesion, cell fusion, and cell signaling properties. It is involved in ectodomain shedding of membrane proteins and is associated with inflammation and neurodegeneration. ADAM8 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived ADAM8 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM8 Protein, Rhesus Macaque (HEK293, His) is 477 a.a., with molecular weight of ~53.4 KDa.

Rhesus Macaque

In response to inflammatory stimuli such as lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF-α), ADAM8 expression is upregulated in macrophages and activated glial cells (astrocytes and microglia) in the central nervous system (CNS), suggesting its involvement in neuronal-glial signaling. ADAM8 has proteolytic, cell adhesion, cell fusion, and cell signaling properties. It is involved in ectodomain shedding of membrane proteins and is associated with inflammation and neurodegeneration [1] [2] .

ADAM 8; ADAM metallopeptidase domain 8; CD156a; MS2

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 12 mM Tris-HCL, 5 mM CaCl 2 , 75 mM NaCl, pH 7.4, 50% Glycerol.

Shipping with dry ice