protein

USP46 Protein, Human/Mouse (sf9)

HY-P77277

100 μg

540 USD

USP46 Protein, Human/Mouse (sf9)

proteins

Sf9 insect cells

100 μg

540 USD

USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9) is the recombinant human, mouse-derived USP46 protein, expressed by Sf9 insect cells , with tag free. The total length of USP46 Protein, Human/Mouse (sf9) is 366 a.a., with molecular weight of ~43 kDa.

Human;Mouse

USP46 protein, a deubiquitinating enzyme, is implicated in behavioral regulation, potentially through the modulation of GABA action. Its role may involve mediating the deubiquitination of GAD1/GAD67, as suggested by studies. Interestingly, USP46 exhibits minimal deubiquitinating activity on its own and relies on interaction with WDR48 to achieve high enzymatic activity. Contrary to its involvement in GABA-related processes, USP46 is not engaged in the deubiquitination of monoubiquitinated FANCD2, indicating specificity in its substrate interactions (By similarity). This multifaceted enzyme sheds light on the intricate regulatory mechanisms underlying behavior and neurotransmitter dynamics.

Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Usp46

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10% Glycerol. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.