protein

TWSG1 Protein, Mouse (HEK293, His)

HY-P77267

5 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

TWSG1 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

The TWSG1 protein may contribute to the formation of the dorsal-ventral axis by counteracting BMP signaling and forming a ternary complex with CHRD and BMP to prevent BMP from binding to the receptor. Notably, TWSG1 exhibits anti-BMP and pro-BMP activities. TWSG1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TWSG1 protein, expressed by HEK293 , with C-His labeled tag. The total length of TWSG1 Protein, Mouse (HEK293, His) is 198 a.a., with molecular weight of ~34 kDa.

Mouse

TWSG1 protein is potentially involved in the formation of the dorsoventral axis. It appears to exert its function by counteracting BMP signaling through the formation of ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. Interestingly, TWSG1 exhibits both anti-BMP and pro-BMP activities. It achieves the latter by cleaving and degrading CHRD, leading to the release of BMPs from the ternary complexes. This dual role suggests that TWSG1 may be a crucial regulator of BMP-mediated processes, particularly in cartilage development and chondrocyte differentiation. Additionally, it may also play a role in thymocyte development. TWSG1 interacts with CHRD and/or BMP4, enhancing the formation of CHRD/BMP4 complexes, and it also interacts with BMP7. Further investigations are needed to fully comprehend the precise mechanisms and signaling pathways through which TWSG1 operates.

Twisted Gastrulation Protein Homolog 1; TWSG1; TSG

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.