protein

TAOK3 Protein, Human (sf9, His)

HY-P77222

5 μg;10 μg;50 μg

68;108;300 USD

TAOK3 Protein, Human (sf9, His)

proteins

Sf9 insect cells

5 μg;10 μg;50 μg

68;108;300 USD

TAOK3, a kinase, regulates the p38/MAPK14 and MAPK8/JNK cascades. It activates the p38/MAPK14 cascade, particularly in DNA damage-induced G2/M transition, likely through MAP2K3 and MAP2K6 phosphorylation. TAOK3 inhibits basal MAPK8/JNK activity and dampens its response to epidermal growth factor. These functions showcase TAOK3's role in coordinating cellular responses to DNA damage and growth factor signaling. TAOK3 Protein, Human (sf9, His) is the recombinant human-derived TAOK3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of TAOK3 Protein, Human (sf9, His) is 411 a.a.

Human

TAOK3, a serine/threonine-protein kinase, functions as a regulator of the p38/MAPK14 stress-activated MAPK cascade and the MAPK8/JNK cascade. It acts as an activator of the p38/MAPK14 cascade, particularly in response to DNA damage, where it plays a role in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 cascade. This activation is likely mediated through the phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Moreover, TAOK3 serves as an inhibitor of the basal activity of the MAPK8/JNK cascade and reduces its activation in response to epidermal growth factor (EGF). These regulatory functions highlight TAOK3's role in coordinating cellular responses to DNA damage and growth factor signaling.

Serine/threonine-protein kinase TAO3; JNK/SAPK-inhibitory kinase; DPK; JIK; KDS; MAP3K18

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCL, 500 mM NaCl, pH 8.0, 10% Glycerol.

Shipping with dry ice