protein

SLC27A4/FATP4 Protein, Human (HEK293, His)

HY-P77206

5 μg;10 μg;50 μg;100 μg

55;85;220;350 USD

SLC27A4/FATP4 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

55;85;220;350 USD

The SLC27A4/FATP4 protein centrally regulates cellular processes by regulating the levels of long-chain fatty acids (LCFA), which are critical for their transport across membranes. As the major LCFA transporter in small intestinal enterocytes, it plays a key role in early embryonic fat absorption. SLC27A4/FATP4 Protein, Human (HEK293, His) is the recombinant human-derived SLC27A4/FATP4 protein, expressed by HEK293 , with N-His labeled tag. The total length of SLC27A4/FATP4 Protein, Human (HEK293, His) is 161 a.a., with molecular weight of ~25 kDa.

Human

SLC27A4/FATP4 Protein assumes a central role in cellular processes by mediating the levels of long-chain fatty acids (LCFA) within the cell, facilitating their transport across cell membranes. Widely implicated in fatty acid regulation, this protein appears to be the principal fatty acid transporter in small intestinal enterocytes, playing a crucial role in fat absorption during early embryogenesis. Additionally, SLC27A4/FATP4 functions as an acyl-CoA ligase, catalyzing the ATP-dependent formation of fatty acyl-CoA from LCFA and very-long-chain fatty acids (VLCFA) substrates. This catalytic activity not only prevents fatty acid efflux from cells but also potentially enhances fatty acid uptake. The protein is further involved in the formation of the epidermal barrier and likely participates in fatty acid transport across the blood barrier. Indirectly inhibiting RPE65 via substrate competition and the production of VLCFA derivatives such as lignoceroyl-CoA, SLC27A4/FATP4 contributes to the prevention of light-induced degeneration of rods and cones, highlighting its diverse and vital roles in cellular and physiological processes.

Long-chain fatty acid transport protein 4; Arachidonate--CoA ligase; ACSVL4

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.