protein

Serpin D1 Protein, Human (HEK293, His)

HY-P77199

5 μg;10 μg;50 μg;100 μg

60;100;280;530 USD

Serpin D1 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

60;100;280;530 USD

Serpin D1 protein is a thrombin inhibitor activated by glycosaminoglycans such as heparin or dermatan sulfate. It replaces antithrombin III and becomes the main thrombin inhibitor in the presence of dermatan sulfate. In addition to thrombin inhibition, serpin D1 also has glycosaminoglycan-independent chymotrypsin inhibitory activity. Serpin D1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin D1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin D1 Protein, Human (HEK293, His) is 480 a.a., with molecular weight of ~75-80 kDa.

Human

Serpin D1 Protein functions as a thrombin inhibitor, with its activity activated by glycosaminoglycans such as heparin or dermatan sulfate. In the presence of dermatan sulfate, HC-II becomes the predominant thrombin inhibitor, displacing antithrombin III (AT-III). Beyond its role in thrombin inhibition, Serpin D1 also exhibits chymotrypsin-inhibiting activity, independent of glycosaminoglycans. Notably, peptides at the N-terminal of HC-II demonstrate chemotactic activity for both monocytes and neutrophils. This multifaceted functionality highlights the diverse roles of Serpin D1 in regulating protease activities and participating in immune responses, underscoring its significance in maintaining hemostasis and modulating inflammatory processes.

Heparin cofactor 2; Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.