protein

RGMB Protein, Mouse (HEK293, His)

HY-P77178

5 μg;10 μg

60;100 USD

RGMB Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg

60;100 USD

RGMB, a member of the RGM family, shapes the developing nervous system as a BMP coreceptor. It enhances BMP signaling and modulates neuronal adhesion. RGMB forms homooligomers and interacts with DRGX, BMP2, BMP4, ACVR1, BMPR1A, BMPR1B, and ACVR2B. It also forms a functional complex with NEO1/neogenin, activating downstream signaling via RhoA. RGMB Protein, Mouse (HEK293, His) is the recombinant mouse-derived RGMB protein, expressed by HEK293 , with C-His, C-10*His labeled tag. The total length of RGMB Protein, Mouse (HEK293, His) is 367 a.a., with molecular weight of ~40.2 KDa.

Mouse

Repulsive guidance molecule B (RGMB), a member of the repulsive guidance molecule (RGM) family, plays a pivotal role in shaping the developing nervous system. Functioning as a bone morphogenetic protein (BMP) coreceptor, RGMB enhances BMP signaling and contributes to the modulation of neuronal adhesion. While potentially inhibiting neurite outgrowth, RGMB forms homooligomers and interacts with DRGX, BMP2, BMP4, as well as BMP type I receptors (ACVR1, BMPR1A, BMPR1B) and BMP type II receptor (ACVR2B). Notably, RGMB forms a functional complex with its receptor NEO1/neogenin, arranged as a heterotetramer with a 2:2 stoichiometry, where RGMB molecules act as staples bringing two NEO1 receptors together without engaging themselves. This arrangement leads to the activation of downstream signaling via RhoA.

Repulsive guidance molecule B; RGM-B

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.