protein

PTK9 Protein, Human

HY-P77167

5 μg;10 μg;50 μg;100 μg;500 μg

45;75;200;340;950 USD

PTK9 Protein, Human

proteins

E. coli

5 μg;10 μg;50 μg;100 μg;500 μg

45;75;200;340;950 USD

PTK9, an actin-binding protein, regulates motility and morphological processes by inhibiting actin polymerization and capping the barbed ends of filaments. It plays a crucial role in clathrin-mediated endocytosis and the distribution of endocytic organelles. PTK9 interacts with G-actin, capping protein (CP), and possibly TWF2 and phosphoinositides, particularly PI(4,5)P2, which down-regulates its activity. Additionally, it interacts with ACTG1. PTK9 Protein, Human is the recombinant human-derived PTK9 protein, expressed by E. coli , with tag free. The total length of PTK9 Protein, Human is 252 a.a., with molecular weight of ~33 kDa.

Human

PTK9, an actin-binding protein, actively participates in motile and morphological processes, exerting its influence on actin polymerization by likely sequestering G-actin. Through its capacity to cap the barbed ends of filaments, PTK9 plays a regulatory role in cellular motility. Furthermore, its involvement in clathrin-mediated endocytosis and the distribution of endocytic organelles suggests a multifaceted role in cellular dynamics. PTK9 interacts with G-actin, particularly the ADP-actin form, and with capping protein (CP), highlighting its intricate involvement in actin-related processes. Additionally, it may have interactions with TWF2 and phosphoinositides, particularly PI(4,5)P2, where binding to the latter results in down-regulation. Moreover, PTK9 has been observed to interact with ACTG1, further expanding its network of molecular associations.

Twinfilin-1; Protein A6; Protein tyrosine kinase 9; TWF1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 8.0.

Room temperature in continental US; may vary elsewhere.