protein

Calumenin Protein, Human (HEK293, His)

HY-P7713

5 μg;10 μg;50 μg;100 μg

55;93;260;440 USD

Calumenin Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

55;93;260;440 USD

Calumenin Protein, Human (HEK293, His), a recombinant human Calumenin produced in HEK293 cells, has a His tag at the N-terminus. Calumenin protein (CP) is located within the endoplasmic reticulum Ca 2+ binding proteins. Calumenin as a suppressor of cell migration and tumor metastasis. Calumenin binds to and stabilizes fibulin-1, leading to inactivation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling [1] [2] .

Human

Calumenin, belonging to the CREC protein family, is a multiple EF-hand Ca 2+ -binding protein, and has been found to have unique C-terminal SR retention signal HDEF. CP can combine with ryanodine receptor to active sarcoplasmic reticulum Ca 2+ ATPase (SERCA2a) to regulate the release of intracellular calcium, intake, and storage of calcium in order to maintain homeostasis of calcium cycling. CP can also relieve ERS of myocardial cells and suppress ERS-mediated apoptosis. CP can relieve ERS-initiated apoptosis in viral myocarditis [1] .

rHuCalumenin, His; Calumenin; Crocalbin; IEF SSP 9302; CALU

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.0.

Room temperature in continental US; may vary elsewhere.