protein

ADCYAP1R1 Protein, Human (HEK293, Fc)

HY-P77120

5 μg;10 μg;50 μg

60;105;290 USD

ADCYAP1R1 Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg

60;105;290 USD

The ADCYAP1R1 protein is a receptor for pituitary adenylate cyclase-activating polypeptide (PACAP) and recognizes PACAP-27 and PACAP-38. Through the G protein, this receptor activates adenylyl cyclase, initiating multiple downstream signaling pathways. ADCYAP1R1 Protein, Human (HEK293, Fc) is the recombinant human-derived ADCYAP1R1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ADCYAP1R1 Protein, Human (HEK293, Fc) is 155 a.a., with molecular weight of ~65 kDa.

Human

The ADCYAP1R1 protein functions as a receptor for pituitary adenylate cyclase-activating polypeptide (PACAP), specifically recognizing both PACAP-27 and PACAP-38. Operating through G proteins, this receptor activates adenylyl cyclase, initiating downstream signaling pathways. It is implicated in the regulation of various hormonal releases, including adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. Additionally, ADCYAP1R1 may play a role in spermatogenesis and sperm motility, contributing to smooth muscle relaxation and secretion in the gastrointestinal tract. Its interaction with PACAP is facilitated through the N-terminal extracellular domain, highlighting its crucial involvement in diverse physiological processes.

Pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP-R1; ADCYAP1R1

Greater than 88% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

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