protein

NOTCH2NL Protein, Human (HEK293, Fc)

HY-P77107

5 μg;10 μg;50 μg

55;85;215 USD

NOTCH2NL Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg

55;85;215 USD

NOTCH2NL is a human-specific protein that promotes neural progenitor cell proliferation through Notch signaling regulation, thereby crucially driving the evolutionary expansion of the neocortex. By enhancing self-renewal and downregulating neuronal differentiation genes, NOTCH2NL delays progenitor cell maturation and promotes increased neuronal production. NOTCH2NL Protein, Human (HEK293, Fc) is the recombinant human-derived NOTCH2NL protein, expressed by HEK293 , with N-mFc labeled tag. The total length of NOTCH2NL Protein, Human (HEK293, Fc) is 236 a.a., with molecular weight of 55-75 KDa.

Human

NOTCH2NL, a human-specific protein, plays a pivotal role in the evolutionary expansion of the neocortex by orchestrating neural progenitor proliferation through modulation of the Notch signaling pathway. By promoting self-renewal of neural progenitors, NOTCH2NL potentially down-regulates genes associated with neuronal differentiation, thereby delaying the maturation of neuronal progenitors and ultimately fostering increased neuronal production. Its influence on the Notch signaling pathway occurs through two parallel mechanisms: firstly, via direct interaction with NOTCH2, enhancing Notch signaling in a non-cell-autonomous manner; and secondly, by autonomously inhibiting cis DLL1-NOTCH2 interactions, thereby promoting sustained neural progenitor status and inhibiting premature neuronal differentiation. These intricate interactions contribute to the unique regulatory role of NOTCH2NL in shaping the complex dynamics of human neurogenesis. Additionally, NOTCH2NL forms direct interactions with ELANE and DLL1, further highlighting its multifaceted involvement in cellular processes.

Notch homolog 2 N-terminal-like protein A; NOTCH2NLA; N2N

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.