protein

Ninjurin-1 Protein, Rat (HEK293, Fc)

HY-P77104

5 μg;10 μg;50 μg

57;96;270 USD

Ninjurin-1 Protein, Rat (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg

57;96;270 USD

The Ninjurin-1 protein is a key player in programmed cell death, driving plasma membrane rupture in the necroptosis and pyroptosis pathways.Ninjurin-1 oligomerizes downstream of gasdermin or MLKL activation, inducing cell lysis and releasing inflammatory DAMPs.Ninjurin-1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived Ninjurin-1 protein, expressed by HEK293 , with N-hFc labeled tag.

Rat

Ninjurin-1 Protein serves as a pivotal effector in programmed cell death, orchestrating plasma membrane rupture during necroptotic and pyroptotic pathways. Downstream of Gasdermin or MLKL activation, Ninjurin-1 oligomerizes, introducing hydrophilic faces into the membrane and inducing cytolysis, releasing damage-associated molecular patterns (DAMPs) that fuel the inflammatory response. Additionally, it regulates Toll-like receptor 4 signaling triggered by lipopolysaccharide during systemic inflammation by directly binding LPS. In inflammation, Ninjurin-1 promotes leukocyte migration and transendothelial migration of macrophages, facilitating monocyte recruitment to inflammatory sites and mitigating atherosclerosis. Beyond its role in inflammation, Ninjurin-1 acts as a homophilic transmembrane adhesion molecule, contributing to processes such as axonal growth, angiogenesis, and osteoclast development. Its secreted form exhibits chemotactic activity, enhancing monocyte recruitment and acting as an anti-inflammatory mediator in atherosclerosis.

Nerve injury-induced protein 1; NIN1; NINJ1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.