protein

NCKIPSD Protein, Human (His)

HY-P77099

5 μg;10 μg

55;90 USD

NCKIPSD Protein, Human (His)

proteins

E. coli

5 μg;10 μg

55;90 USD

NCKIPSD Protein, vital for stress fiber formation induced by active DRF1, stimulates N-WASP-induced ARP2/3 complex activation, independent of CDC42. Implicated in sarcomere maintenance, myofibril assembly, actin polymerization, and angiogenesis. Associates with vimentin, desmin, NCK, GRB2, and interacts with Helicobacter pylori toxin vacA, FHOD1, FASLG, and TMIGD2, showcasing its diverse cellular interactions. NCKIPSD Protein, Human (His) is the recombinant human-derived NCKIPSD protein, expressed by E. coli , with N-His labeled tag. The total length of NCKIPSD Protein, Human (His) is 244 a.a., with molecular weight of ~33-45 kDa.

Human

NCKIPSD Protein plays a crucial role in the formation of stress fibers induced by active diaphanous protein homolog 1 (DRF1) and promotes microspike formation in vivo. It also stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 in vitro. Additionally, it is involved in the maintenance of sarcomeres and the assembly of myofibrils into sarcomeres, contributing to actin polymerization and cell adhesion regulation. NCKIPSD Protein is implicated in angiogenesis and associates with intermediate filaments such as vimentin and desmin. It binds to the SH3 domains of NCK, GRB2, and diaphanous protein homolog 1 (DRF1), as well as the proline-rich domains of N-WASP. It interacts with Helicobacter pylori toxin vacA, FHOD1 (isoform 4), FASLG, and TMIGD2.

NCK-interacting protein with SH3 domain; VIP54; WISH; AF3P21; SPIN90

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.