protein

MBL1 Protein, Rat (HEK293, Fc)

HY-P77079

2 μg;5 μg;10 μg

55;100;150 USD

MBL1 Protein, Rat (HEK293, Fc)

proteins

HEK293

2 μg;5 μg;10 μg

55;100;150 USD

MBL1 protein is a calcium-dependent lectin that participates in innate immunity by binding to mannose, fucose and N-acetylglucosamine on microorganisms and activating the lectin complement pathway.MBL1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived MBL1 protein, expressed by HEK293 , with C-hFc labeled tag.

Rat

MBL1, a calcium-dependent lectin, plays a crucial role in the innate immune response by binding to mannose, fucose, and N-acetylglucosamine moieties on various microorganisms, thereby activating the lectin complement pathway. Beyond its involvement in host defense, MBL1 exhibits affinity for late apoptotic cells, apoptotic blebs, and necrotic cells, facilitating their uptake by macrophages. The protein forms homotrimers and assembles into higher oligomeric complexes through the association of two, three, or more homotrimers, a process occurring in the endoplasmic reticulum. This oligomerization pattern underscores the structural complexity of MBL1. Additionally, MBL1 interacts with MASP1 and MASP2, further connecting its role in lectin-mediated immune responses and complement activation.

Mannose-binding protein A; MBP-A; RaRF p28B

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.