protein

KIRREL3/NEPH2 Protein, Rat (HEK293, His)

HY-P77046

5 μg;10 μg;50 μg

40;70;200 USD

KIRREL3/NEPH2 Protein, Rat (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

40;70;200 USD

The KIRREL3/NEPH2 protein plays a critical role in the formation of precise synapses, particularly in hippocampal mossy fiber synapses, where it is responsible for coordinating mossy fiber filopodia. It acts in a homologous manner to stabilize filopodia contacts and facilitate subsequent synapse formation. KIRREL3/NEPH2 Protein, Rat (HEK293, His) is the recombinant rat-derived KIRREL3/NEPH2 protein, expressed by HEK293 , with C-His labeled tag. The total length of KIRREL3/NEPH2 Protein, Rat (HEK293, His) is 502 a.a., with molecular weight of 60-64 kDa.

Rat

The KIRREL3/NEPH2 protein emerges as a pivotal synaptic adhesion molecule essential for the precise formation of target-specific synapses, particularly notable at hippocampal mossy fiber synapses. Its significance extends to the orchestration of mossy fiber filopodia, critical synaptic structures linking dentate granule and GABA neurons. Functionally, KIRREL3/NEPH2 likely serves as a homophilic adhesion molecule, fostering trans-cellular interactions and playing a key role in stabilizing mossy fiber filipodia contacts, thereby facilitating subsequent synapse formation. Beyond the hippocampus, KIRREL3/NEPH2 is vital for the coalescence of vomeronasal sensory neuron axons. Moreover, it may play a role in the hematopoietic supportive capacity of stroma cells, with its secreted extracellular domain directly supporting hematopoietic stem cells. Functioning as a homodimer, KIRREL3/NEPH2 mediates homophilic interactions crucial for promoting cell adhesion. Additionally, it engages in a spectrum of protein-protein interactions, including the formation of heterodimers with NPHS1, interactions with NPHS2/podocin, CASK, MAP1B, MYO16, ATP1B1, SHMT2, and UFC1, underscoring its multifaceted and integral role in diverse cellular processes.

Kin of IRRE-like protein 3; Nephrin-like protein 2; Kiaa1867; Neph2

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.