protein

IL-22R alpha 1 Protein, Rat (HEK293, Fc)

HY-P77001

5 μg;10 μg;50 μg;100 μg

53;89;250;425 USD

IL-22R alpha 1 Protein, Rat (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

53;89;250;425 USD

IL-22R alpha 1 (IL22RA1) Protein is an IL-22 receptor. IL-22R alpha 1 Protein interacts with IL-22 to activate the JAK/STAT cascade thereby inhibits IL-22 mediated promotion of cell proliferation and anti-apoptosis. IL-22R alpha 1 Protein, Rat (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region (M1-A228) with a Fc tag at the C-terminus [1] .

Rat

IL-22R alpha 1 (IL22RA1) Protein is a single-pass type I membrane protein. IL-22R alpha 1 expresses in colon, liver, lung, pancreas and kidney. IL-22R alpha 1 is primarily present on epithelial cells and certain monocyte subsets, and very limited IL-22R alpha 1 expression is found on other immune cells [1] [2] . The sequence of amino acids in IL-22R alpha 1 from different species is very different (less than 85% similarity among human, rat and Canine). IL-22R alpha 1 is an essential component of the high-affinity IL-22 receptor enabling IL-22 signaling via JAK/STAT pathways. IL-22R alpha 1 is a component of one of the receptors for IL-20 and IL-24 formed and signaling through STATs activation. IL-22R alpha 1 mediates IL-24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation [2] [3] .

Interleukin-22 receptor subunit alpha-1; IL-22R-alpha-1; CRF2-9; ZcytoR11; IL22R

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.