protein

IL1RAPL1 Protein, Mouse (HEK293, Fc)

HY-P76998

5 μg;10 μg;50 μg;100 μg;500 μg

40;70;200;340;1050 USD

IL1RAPL1 Protein, Mouse (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

40;70;200;340;1050 USD

IL1RAPL1 protein inhibits N-type calcium channels, regulates secretion, and activates JNK signaling. It promotes neurite growth and bidirectionally induces presynaptic and postsynaptic differentiation by binding to PTPRD during dendritic spine formation. IL1RAPL1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL1RAPL1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL1RAPL1 Protein, Mouse (HEK293, Fc) is 333 a.a., with molecular weight of ~85-95 kDa.

Mouse

The IL1RAPL1 protein appears to exert regulatory control over secretion and presynaptic differentiation by inhibiting the activity of N-type voltage-gated calcium channels. Additionally, it may activate the MAP kinase JNK, suggesting a potential role in intracellular signaling pathways. Furthermore, IL1RAPL1 is implicated in neurite outgrowth, indicating its involvement in the extension of neuronal processes. Notably, during dendritic spine formation, IL1RAPL1 can bidirectionally induce both pre- and post-synaptic differentiation of neurons through trans-synaptic binding to PTPRD. This multifaceted functionality underscores IL1RAPL1's significance in modulating various aspects of neuronal development and synaptic differentiation, with potential implications for neural circuit formation and function. Further investigation into the specific mechanisms and downstream effects of IL1RAPL1 in these processes could provide valuable insights into its role in neurodevelopment.

Interleukin-1 Receptor Accessory Protein-Like 1; Oligophrenin-4; OPHN4

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.