protein

IL-10R alpha Protein, Rhesus Macaque (HEK293, Fc)

HY-P76987

10 μg;50 μg

150;420 USD

IL-10R alpha Protein, Rhesus Macaque (HEK293, Fc)

proteins

HEK293

10 μg;50 μg

150;420 USD

IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines.IL-10R alpha Protein, Rhesus Macaque (HEK293, Fc) is expressed in HEK 293 cells and consists of 590 amino acids (M1-S590) with a -hFc tag at the C-terminus [1] .

Rhesus Macaque

IL-10R alpha is a ligand-binding subunit of the type II cytokine receptor consisting of 2 alpha and 2 beta subunits and is expressed primarily in hematopoietic cells such as B cells, T cells, NK cells, monocytes and macrophages, but not in non-hematopoietic cells such as fibroblasts or endothelial cells [1] . IL-10R alpha binds to the ligand and leads to a conformational change in the beta subunit, which results in the beta subunit also binding IL-10, forming a heterotetramer that leads to activation of the signalling complex of JAK1 and TYK2 kinases. In this case, JAK1 binds to the alpha subunit and TYK2 binds to the beta subunit, phosphorylating specific tyrosine residues in the intracellular structural domain of IL10R alpha. This further leads to phosphorylation and activation of the transcription factor STAT3, which dimerises STAT3 monomers into the nucleus and induces transcriptional expression of the target gene [1] . IL-10R alpha is involved in suppressing inflammatory responses and Th 1 cell-mediated immune responses, and also regulates neutrophil functional responses. In addition, IL10R alpha-mediated activation of STAT3 also inhibits starvation-induced autophagy [2] .

Interleukin-10 receptor subunit alpha; IL-10RA; CDw210a; IL-10R1; CD210

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice