protein

IFN-alpha 4/IFNA4 Protein, Rat (HEK293, Fc)

HY-P76983

2 μg;10 μg;50 μg;100 μg

32;85;215;340 USD

IFN-alpha 4/IFNA4 Protein, Rat (HEK293, Fc)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

32;85;215;340 USD

IFN-alpha 4 (IFNA4), belongs to type I interferon family, is produced by macrophages with antiviral activities [1] . IFN-alpha 4/IFNA4 Protein, Rat (HEK293, Fc) contains 166 a.a. (C24-K189), produced in HEK293 cells with a N-terminal hFc-tag.

Rat

IFN-alpha 4 (IFNA4; IFN-α4), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively [1] . Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia [2] . IFN-alpha 4 is the subtypes dominates in IFN-alpha, whose the response with IFNA5, IFNA7, and IFNA14 accounting for up to 85% of the subtypes expressed by Peripheral blood mononuclear cells (PBMCs) [3] . IFN-alpha 4 is promoted by interferon (IFN) regulatory factors (IRFs), especially IRF-1 and IRF-7 [5] [6] . And it exhibits function by inhibiting virus RNA replication and enhances human natural killer cytotoxicity against virus [4] [7] . As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA4 protein of rat shows 80.98% similarity with mouse, but is very different from human (57.98%).

Interferon alpha-4; Interferon alpha-4B; Interferon alpha-76

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.