protein

CA125 Protein, Human (HEK293, His)

HY-P7696

5 μg;10 μg;50 μg;100 μg

70;120;350;600 USD

CA125 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

70;120;350;600 USD

CA125 is a giant mucin-like glycoprotein expressed by epithelial ovarian neoplasms and cells, which is an antigenic tumor marker. CA125 provides a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. CA125 binds to mesothelin (MSLN) mediates heterotypic cell adhesion, contributing to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium. CA125 is widely used for monitoring with ovarian epithelial cancer. CA125 Protein, Human (HEK293, His) is a recombinant human cancer antigen 125 (CA125) with a His label and is expressed in HEK293 cells [1] [2] [3] [4] [5] [6] [7] .

Human

CA125 Protein (Human) is a counter receptor for galectin-1, as both soluble and membrane-associated fragments of CA125 derived from HeLa cell lysates are shown to bind specifically to human galectin-1 with high efficiency [1] . CA125 Protein (Human) is one of the mucin family proteins and is a serum tumor marker for various tumors, such as ovarian cancer, endometrial cancer, pancreatic cancer and bladder cancer [2] . CA-125 Protein (Human) is correlated with both peritoneal carcinomatosis on the diaphragm and residual disease (RD): A CA-125 (Human) value above 500 U/ml induction on the risk of diaphragmatic carcinomatosis is 3.5 times higher and the risk for residual disease of any size is increased by 2.4 times [3] . CA125 Protein (Human) is an antigen epitope found on mucin 16 (MUC16), a glycoprotein antigen present on the cell surface. Currently, 3 antibodies can help identify the CA125 antigen: OC125-like antibodies, M11-like antibodies and OV197-like antibodies. Postmenopausal women with a CA125 Protein (Human) level higher than 35 U/mL are considered to have a high risk of a malignancy [4] . CA125 Protein (Human) affects the cellular function of cancer cells, including fending off cytotoxic natural killer cell at

rHuCA125, His; CA125 ovarian cancer antigen; CA125; CA125MUC-16;

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 50 mM Tris, 100 mM Glycine, pH 7.5 or 50 mM Tris-HCL, 300 mM NaCl, 100 mM Glycine, pH 7.4.

Room temperature in continental US; may vary elsewhere.