protein

GGH/Glutamyl hydrolase gamma Protein, Human (HEK293, His)

HY-P76953

5 μg;10 μg;50 μg;100 μg

52;88;247;420 USD

GGH/Glutamyl hydrolase gamma Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

52;88;247;420 USD

GGH (Glutamyl hydrolase gamma) protein hydrolyzes polyglutamate sidechains in pteroylpolyglutamates, progressively removing gamma-glutamyl residues to produce pteroyl-alpha-glutamate (folic acid) and free glutamate. Studies indicate GGH's crucial role in modulating the bioavailability of dietary pteroylpolyglutamates and its significance in the metabolism of both pteroylpolyglutamates and antifolates. GGH/Glutamyl hydrolase gamma Protein, Human (HEK293, His) is the recombinant human-derived GGH/Glutamyl hydrolase gamma protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of GGH/Glutamyl hydrolase gamma Protein, Human (HEK293, His) is 294 a.a., with molecular weight of ~40 KDa.

Human

GGH (Glutamyl hydrolase gamma) protein is instrumental in the hydrolysis of polyglutamate sidechains present in pteroylpolyglutamates. Its enzymatic activity involves the progressive removal of gamma-glutamyl residues from pteroylpoly-gamma-glutamate, resulting in the generation of pteroyl-alpha-glutamate (folic acid) and free glutamate. This process, as elucidated by studies, suggests that GGH may hold a pivotal role in modulating the bioavailability of dietary pteroylpolyglutamates, and also plays a significant role in the metabolism of both pteroylpolyglutamates and antifolates.

Gamma-glutamyl hydrolase; Conjugase; GH; Gamma-Glu-X carboxypeptidase

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.