protein

GFRA2/GDNFR-alpha-2 Protein, Mouse (HEK293, His)

HY-P76950

2 μg;10 μg;50 μg

30;75;215 USD

GFRA2/GDNFR-alpha-2 Protein, Mouse (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg

30;75;215 USD

GFRA2/GDNFR-α-2 protein acts as a receptor for neurotrophic factors and promotes NRTN-induced autophosphorylation and RET receptor activation. It also mediates GDNF signaling through the RET tyrosine kinase receptor. GFRA2/GDNFR-alpha-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GFRA2/GDNFR-alpha-2 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

GFRA2/GDNFR-alpha-2 Protein serves as the receptor for neurturin, facilitating the NRTN-induced autophosphorylation and activation of the RET receptor. Additionally, it plays a role in mediating GDNF signaling through the RET tyrosine kinase receptor. Notably, GFRA2/GDNFR-alpha-2 is involved in the NRTN-induced phosphorylation of STAT3 at 'Ser-727,' highlighting its participation in signaling pathways associated with cell responses. These interactions underscore the significance of GFRA2 in transducing signals that regulate cellular processes and contribute to the intricate network of signaling events involved in neuronal development and maintenance.

GDNF Family Receptor Alpha-2; GFR-Alpha-2; GDNFR-Beta; NRTNR-Alpha; GDNFRB; RETL2; TRNR2

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.