protein

GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, His)

HY-P76949

2 μg;10 μg;50 μg;100 μg

35;93;210;340 USD

GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

35;93;210;340 USD

GFRA1/GDNFR-α-1 protein is a receptor for GDNF and critically mediates GDNF-induced autophosphorylation and RET receptor activation.Presumably, two GDNFR-α-1 molecules form a complex with disulfide-linked GDNF, two RET molecules, and SORL1, suggesting the existence of a coordinated signaling mechanism.GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, His) is the recombinant rat-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-His, C-6*His labeled tag.

Rat

GFRA1/GDNFR-alpha-1 Protein serves as a receptor for GDNF and plays a crucial role in mediating the GDNF-induced autophosphorylation and activation of the RET receptor. It is proposed that two molecules of GDNFR-alpha-1 form a complex with the disulfide-linked GDNF dimer and two molecules of RET, suggesting a coordinated mechanism for signal transduction. GFRA1 interacts with RET, facilitating the intricate signaling pathways associated with GDNF-induced responses. Additionally, GFRA1 engages in interactions with SORL1, either alone or in a complex with GDNF. This interaction results in the internalization of GFRA1, without leading to its degradation, indicating a regulatory aspect of GFRA1 dynamics. These molecular interactions highlight the multifaceted role of GFRA1 in mediating GDNF signaling and emphasize its importance in cellular processes.

GFRα1; GDNF Family Receptor Alpha-1; GFR-Alpha-1; RET Ligand 1; GDNFRA; RETL1; TRNR1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.